abstract：BACKGROUND:Aspirin-resistant platelet activation in whole blood is attributable to a transcellular pathway not detected by isolated platelet aggregometry. Aspirin resistance as defined by urinary thromboxane levels is associated with increased risk for myocardial infarction or cardiac death. Whole blood point-of-care a...

journal_title：Anesthesia and analgesia

authors： Carroll RC,Craft RM,Snider CC,Aligeti VR,Wortham DC

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Cannabinoid agonists induce norepinephrine release in central, spinal, and peripheral sites. Previous studies suggest an interaction between the cannabinoid and adrenergic systems on antinociception. In this study, we sought to verify whether the CB1 and CB2 cannabinoid receptor agonists anandamide and N-pal...

journal_title：Anesthesia and analgesia

authors： Romero TR,Resende LC,Guzzo LS,Duarte ID

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Individualizing arterial blood pressure (ABP) targets during cardiopulmonary bypass (CPB) based on cerebral blood flow (CBF) autoregulation monitoring may provide a more effective means for preventing cerebral hypoperfusion than the current standard of care. Autoregulation can be monitored in real time with ...

journal_title：Anesthesia and analgesia

authors： Ono M,Zheng Y,Joshi B,Sigl JC,Hogue CW

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Mounting evidence from animal studies shows that anesthetic exposure in early life leads to apoptosis in the developing nervous system. This loss of neurons has functional consequences in adulthood. Clinical retrospective reviews have suggested that multiple anesthetic exposures in early childhood are associ...

journal_title：Anesthesia and analgesia

authors： Gentry KR,Steele LM,Sedensky MM,Morgan PG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Regional anesthesia is increasingly used in pediatric patients to provide postoperative analgesia and to supplement intraoperative anesthesia. The Pediatric Regional Anesthesia Network was formed to obtain highly audited data on practice patterns and complications and to facilitate collaborative research in ...

journal_title：Anesthesia and analgesia

authors： Polaner DM,Taenzer AH,Walker BJ,Bosenberg A,Krane EJ,Suresh S,Wolf C,Martin LD

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:We have recently shown that levetiracetam, administered systemically, exerts an antihyperalgesic effect in a rat inflammatory pain model. In this study, we examined whether levetiracetam has local peripheral antihyperalgesic/anti-edematous effects in the same model of localized inflammation and whether opioi...

journal_title：Anesthesia and analgesia

authors： Stepanović-Petrović RM,Micov AM,Tomić MA,Ugrešić ND

更新日期：2012-12-01 00:00:00

abstract：:The safety and utility of pediatric epidural analgesia is well established, but the risk of permanent neurological injury is unknown and largely must be extrapolated from adult literature. In this article we present a series of 4 cases of longterm or permanent neurologic complications associated with epidural analgesi...

journal_title：Anesthesia and analgesia

authors： Meyer MJ,Krane EJ,Goldschneider KR,Klein NJ

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:A single preoperative dose of 600 mg gabapentin, combined with multimodal analgesia, has previously been shown to reduce postcesarean pain and improve maternal satisfaction but was associated with increased maternal sedation. We hypothesized that a lower dose of gabapentin may be effective with less sedation...

journal_title：Anesthesia and analgesia

authors： Short J,Downey K,Bernstein P,Shah V,Carvalho JC

更新日期：2012-12-01 00:00:00

abstract：:Initial attempts at surgical anesthesia began many centuries ago, with the plants of antiquity. The mandragora, or mandrake, was used as a sedative and to induce pain relief for surgical procedures. It has been depicted in tablets and friezes since the 16th century before the common era (BCE) and used for its sedative...

journal_title：Anesthesia and analgesia

authors： Chidiac EJ,Kaddoum RN,Fuleihan SF

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Platelet factor 4 (PF4) is released by activated platelets and has a strong affinity for heparin. Recombinant PF4 (rPF4) has been previously considered as an alternative to protamine for heparin reversal. However, it has been demonstrated that antibodies directed against the PF4/heparin moiety are important ...

journal_title：Anesthesia and analgesia

authors： Demma L,Levy JH

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Bilateral breast augmentation is an increasingly popular day-case procedure. Local infiltration with sedation is routinely used for its ease of application compared with the more complex and potentially riskier paravertebral blockade (PVB). We hypothesized that ropivacaine injected by experienced anesthesia ...

journal_title：Anesthesia and analgesia

authors： Gardiner S,Rudkin G,Cooter R,Field J,Bond M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Anesthesia induction in children is frequently achieved by inhalation of nitrous oxide and sevoflurane. Pediatric anesthesiologists commonly use distraction techniques such as humor or nonprocedural talk to reduce anxiety and facilitate a smooth transition at this critical phase. There is a large body of suc...

journal_title：Anesthesia and analgesia

authors： Mifflin KA,Hackmann T,Chorney JM

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The wide need for analgesia, anesthesia, and sedation in children and the lack of pediatric labeling leads to widespread off-label use of medications for pain and sedation in children. Any attempt to address the lack of labeling will require national estimates of the numbers of children using each medication...

journal_title：Anesthesia and analgesia

authors： Lasky T,Ernst FR,Greenspan J

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The clinical utility of focused transthoracic echocardiography (TTE) is increasingly recognized in perioperative medicine. However its use is limited among anesthesiologists because of a lack of training. The most efficient training methods have not been determined. We hypothesized that simulation-based TTE ...

journal_title：Anesthesia and analgesia

authors： Neelankavil J,Howard-Quijano K,Hsieh TC,Ramsingh D,Scovotti JC,Chua JH,Ho JK,Mahajan A

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:There are profound racial and ethnic disparities in obstetric outcomes in the United States, but little is known about disparities in risk of postpartum hemorrhage (PPH). We explored the association of race and ethnicity on the risk of PPH due to uterine atony with sequential adjustment for possible mediatin...

journal_title：Anesthesia and analgesia

authors： Bryant A,Mhyre JM,Leffert LR,Hoban RA,Yakoob MY,Bateman BT

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine, an α(2)-receptor agonist, prolongs analgesia when used in neuraxial and IV blocks. We evaluated the effect of dexmedetomidine added to ropivacaine for tibial nerve block on the duration of the sensory blockade. METHODS:For this prospective, randomized, controlled, double-blind, crossover tr...

journal_title：Anesthesia and analgesia

authors： Rancourt MP,Albert NT,Côté M,Létourneau DR,Bernard PM

更新日期：2012-10-01 00:00:00

abstract：:The Bonfils Retromolar Intubation Fiberscope is a rigid, straight fiberoptic device with a 40-degree curved tip, which facilitates targeted intubation. Bonfils, using a retromolar approach to intubate tracheas of children with Pierre Robin syndrome, was first described in 1983. After an initial steep learning curve, t...

journal_title：Anesthesia and analgesia

authors： Thong SY,Wong TG

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Propofol-evoked injection site pain is not observed with fospropofol. We hypothesized that unlike propofol, fospropofol does not activate the irritant receptor, transient receptor potential 1 (TRPA1). METHODS:We tested the hypothesis using electrophysiology and behavioral studies. RESULTS:Our data demonstr...

journal_title：Anesthesia and analgesia

authors： Patwardhan A,Edelmayer R,Annabi E,Price T,Malan P,Dussor G

更新日期：2012-10-01 00:00:00

abstract：:Complement activation and the resulting inflammatory response is an important potential mechanism for multisystem organ injury in cardiac surgery. Novel therapeutic strategies using complement inhibitors may hold promise for improving outcomes for cardiac surgical patients by attenuating complement activation or its b...

journal_title：Anesthesia and analgesia

authors： Stahl GL,Shernan SK,Smith PK,Levy JH

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:In the present study, we examined the effects and mechanisms of the Chinese herb resveratrol on attenuation of morphine tolerance in rats. METHODS:Male Wistar rats were implanted with 2 intrathecal catheters; one catheter was connected to a mini-osmotic pump, used for either morphine (15 μg/h) or saline (1 ...

journal_title：Anesthesia and analgesia

authors： Tsai RY,Chou KY,Shen CH,Chien CC,Tsai WY,Huang YN,Tao PL,Lin YS,Wong CS

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Previous modeling of the kinetics of uptake and elimination of anesthetic drugs from the site of action has used measures derived from the electroencephalogram. Such measures lag the current brain activity because of the time needed to acquire a signal sample and derive the measure. With a direct measure of ...

journal_title：Anesthesia and analgesia

authors： Drummond GB,Bleach L,Thomson AJ,Kennedy RR

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Peripheral neuropathy is a common dose-limiting side effect of chemotherapy. There are no clinically proven analgesics for the treatment of this condition. Drugs from different classes have been tested with mixed results. Identification of novel molecular targets for analgesic(s) is important. Antagonism of ...

journal_title：Anesthesia and analgesia

authors： Wala EP,Crooks PA,McIntosh JM,Holtman JR Jr

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Intrathecal drug delivery is an efficient method to administer therapeutic molecules to the central nervous system. However, even with identical drug dosage and administration mode, the extent of drug distribution in vivo is highly variable and difficult to control. Different cerebrospinal fluid (CSF) pulsat...

journal_title：Anesthesia and analgesia

authors： Hsu Y,Hettiarachchi HD,Zhu DC,Linninger AA

更新日期：2012-08-01 00:00:00

abstract：:In recent years the off-label use of recombinant activated factor VII (rFVIIa) has markedly increased, particularly in pediatric cardiac surgery patients, and practitioners differ widely in their usage of the drug. In 2009, the Congenital Cardiac Anesthesia Society (CCAS) assembled a task force to review the literatur...

journal_title：Anesthesia and analgesia

authors： Guzzetta NA,Russell IA,Williams GD

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:A new benzodiazepine, remimazolam, which is rapidly metabolized by tissue esterases to an inactive metabolite, has been developed to permit a fast onset, a short, predictable duration of sedative action, and a more rapid recovery profile than currently available drugs. We report on modeling of the data and s...

journal_title：Anesthesia and analgesia

authors： Wiltshire HR,Kilpatrick GJ,Tilbrook GS,Borkett KM

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:During magnetic resonance imaging (MRI), children are at risk for body temperature variations. The cold MRI environment that preserves the MRI magnet can cause serious hypothermia. On the other hand, hyperthermia may also develop because of radiofrequency-induced heating of the tissues, particularly in pro...

journal_title：Anesthesia and analgesia

authors： Nasr VG,Schumann R,Bonney I,Diaz L,Ahmed I

更新日期：2012-06-01 00:00:00

abstract：:Availability of physiologic monitoring equipment to ensure the safe administration of anesthesia is an expected standard in many parts of the world. Many hospitals in China may not have an adequate quantity and variety of anesthesia delivery and patient monitoring equipment to assure safe administration of anesthesia ...

journal_title：Anesthesia and analgesia

authors： Juan X,Xinqiao F,Shanglong Y,Yuguang H,Buwei Y,Shiying Y,Pengqian F,Hanqing Z

更新日期：2012-06-01 00:00:00

abstract：:A claim of superiority of one intervention over another often depends naturally on results from several outcomes of interest. For such studies the common practice of making conclusions about individual outcomes in isolation can be problematic. For example, an intervention might be shown to improve one outcome (e.g., p...

journal_title：Anesthesia and analgesia

authors： Mascha EJ,Turan A

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Operating rooms contribute significantly to the increasing volumes and costs of hospital waste. Little is known, however, about doctors' views of hospital waste recycling despite their potential influence in improving recycling programs. We surveyed the waste recycling views held by anesthesiologists in Aust...

journal_title：Anesthesia and analgesia

authors： McGain F,White S,Mossenson S,Kayak E,Story D

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Growing awareness of the negative impacts from the practice of health care on the environment and public health calls for the routine inclusion of life cycle criteria into the decision-making process of device selection. Here we present a life cycle assessment of 2 laryngeal mask airways (LMAs), a one-time-u...

journal_title：Anesthesia and analgesia

authors： Eckelman M,Mosher M,Gonzalez A,Sherman J

更新日期：2012-05-01 00:00:00

abstract：:Intraoperative early detection of anemia, identifying toxic levels of carboxyhemoglobin after carbon monoxide exposure and titrating drug dosage to prevent toxic levels of methemoglobin are important goals. The pulse oximeter works by illuminating light into the tissue and sensing the amount of light absorbed. The sam...

journal_title：Anesthesia and analgesia

authors： Shamir MY,Avramovich A,Smaka T

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Topical anesthesia of the upper airway is often recommended when difficulty in airway management is anticipated. There are published reports, however, of administration of topical anesthesia resulting in complete loss of airway control. Adverse effects are mostly attributed to interference with involuntary p...

journal_title：Anesthesia and analgesia

authors： Maxwell MJ,English JD,Moppett IK,McGlashan JA,Norris AM

更新日期：2012-04-01 00:00:00

abstract：:Acute peripheral neuropathic pain after combat-related polytrauma is a common occurrence in the United States military that is often refractory to current drugs and regional anesthesia. Both spinal cord and peripheral nerve stimulation are successfully used for chronic neuropathic pain states, but are not reported for...

journal_title：Anesthesia and analgesia

authors： Kent M,Upp J,Spevak C,Shannon C,Buckenmaier C 3rd

更新日期：2012-04-01 00:00:00

abstract：:Our goal in this study was to develop a robotic intubation system and to conduct a feasibility pilot study on the use of a robotic intubation system for endotracheal intubations. The Kepler Intubation System was developed, consisting of a remote control center (joystick and intubation cockpit) linked to a standard vid...

journal_title：Anesthesia and analgesia

authors： Hemmerling TM,Wehbe M,Zaouter C,Taddei R,Morse J

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:The etiology of postoperative cognitive decline (POCD) remains to be determined. Anesthetic isoflurane, but not desflurane, may induce neurotoxicity. However, the functional consequences of these effects have not been assessed. We therefore performed a pilot study to determine the effects of isoflurane and d...

journal_title：Anesthesia and analgesia

authors： Zhang B,Tian M,Zhen Y,Yue Y,Sherman J,Zheng H,Li S,Tanzi RE,Marcantonio ER,Xie Z

更新日期：2012-02-01 00:00:00

abstract：:It remains questionable whether local anesthetics can interact with membrane lipids at clinically relevant concentrations to show the difference between enantiomers. We compared the effects of bupivacaine stereoisomers on biomimetic membranes containing cardiolipin and cholesterol. Bupivacaine interacted with the memb...

journal_title：Anesthesia and analgesia

authors： Tsuchiya H,Mizogami M

更新日期：2012-02-01 00:00:00

abstract：:Virchow's triad is traditionally invoked to explain pathophysiologic mechanisms leading to thrombosis, alleging concerted roles for abnormalities in blood composition, vessel wall components, and blood flow in the development of arterial and venous thrombosis. Given the tissue-specific bleeding observed in hemophilia ...

journal_title：Anesthesia and analgesia

authors： Wolberg AS,Aleman MM,Leiderman K,Machlus KR

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Recent research suggests that 6% hydroxyethyl starch (HES) 130/0.4 is one of the most frequently used resuscitation fluids worldwide. The retraction of studies evaluating its use necessitates a reevaluation of available evidence regarding its safety and efficacy. METHODS:We performed a systematic review and...

journal_title：Anesthesia and analgesia

authors： Gattas DJ,Dan A,Myburgh J,Billot L,Lo S,Finfer S,CHEST Management Committee.

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia. METHODS:Healthy, term women scheduled for ele...

journal_title：Anesthesia and analgesia

authors： O'Neill P,Duarte F,Ribeiro I,Centeno MJ,Moreira J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that Homer 1b/c, a postsynaptic molecular scaffolding protein that binds and clusters metabotropic glutamate receptors at neuronal synapses, has an important role in the metabotropic glutamate receptor signaling process. In the current study, we investigated the possible in...

journal_title：Anesthesia and analgesia

authors： Yao YX,Jiang Z,Zhao ZQ

更新日期：2011-12-01 00:00:00